Multiple emergency crews responded to a house fire in rural Knoxville this afternoon at 1371 169th Ave.

Neighbors called 911 after they spotted smoke rising from the house, which soon turned to visible flames. Knoxville Township Rural Fire, Knoxville Fire and Rescue, Pella Fire, Pella Rural Fire, the Marion County Sheriff’s Department, and Mid-American Energy were all on scene. Significant damage was caused to the interior and exterior of the home, which may be a total loss. The cause of the fire is unknown, and no injuries were reported. Stay tuned to KNIA/KRLS as more information becomes official.