Those cooking a Thanksgiving day meal today should follow proper food safety guidelines and recommendations. According to the CDC, you should never leave your Turkey to thaw at room temperature, always wash your hands with soap and water for 20 seconds before and after handling the turkey, cook the turkey and accompanied stuffing thoroughly to a minimum temperature of 165 degrees, and refrigerate leftovers within two hours of cooking to prevent food poisoning. Find a full list of Thanksgiving food safety tips below.